Nadiya Moidu - South's Shabana Azmi

As per this article, Her first movie was apparently Nokketha Doorathu Kannum Nattu which was remade in Tamil as Poove Poochooda Vaa.

We have Revathys, Zareena (or Naiya) Moidu's and we also have the rest of the faceless heroines. I mean they - rest of them - do have faces but then who remembers them.

Surprisingly Nadiya's first film was directed by Fazil whose movies are usually out of the ordinary and grab my attention.

Another such director is Rajkumar Hirani: See the table on filmography in the wiki link.